Yes, in some cases. According to the IRS's Summertime Tax Tips (2009), the determining factor is, the expenses must be spent on a job search in your "current occupation" Expenses derived from looking for a job in a "new occupation" are not tax deductible.
Expenses for preparing and mailing copies of your resume are tax deductible, if you are seeking a position in your "current occupation"
If you travel to look for a job in your "current occupation" these expenses are usually deductible.
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If you are looking for a job for the first time or after a long period of not being employed, your job search expenses are not deductible under these circumstances.